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Tuesday, August 30, 2011

Curcumin: A Powdered Gold that Can Help Prevent Alzehiemer’s

Curcumin: A Powdered Gold that Can Help Prevent Alzehiemer’s.  When I first read an article on this topic, Tumeric, some months ago, I was interested, but set it aside as I don't have Alzheimer's as an immediate concern in my life or that of my family.  But when I saw it again, I also noted that there is research on utilizing it not only in neurological disorders but perhaps in "derailing" cancer.

"Looking For A Way to Kick Alzheimer’s?…
In 2008, researchers hypothesized that inflammation may play a role in Alzheimer’s disease. Therefore, it stood to reason that anti-inflammatory NSAIDs should help in the prevention or even treatment of the disease.
To test this theory, they developed the Alzheimer’s Disease Anti-Inflammatory Prevention Trial, or ADAPT.4 More than 2,500 patients enrolled in this randomized, placebo-controlled study.
They were divided into three groups, with the first group receiving 200 mg of celocoxib (Celebrex) twice a day. The second group received 220 mg of naproxen twice a day, and the third group received a placebo.
The study was to last for seven years, but only four years after it began the researchers terminated the study due to safety concerns related to naproxen.
While they found that the NSAIDs did result (to date) in a 30 percent reduction in Alzheimer’s among those patients taking them, they determined that the drug’s side effects (such as gastrointestinal bleeding and liver and kidney damage) weren’t worth the risk. We agree.
Given this, some clever researchers at UCLA were intrigued by the idea that anti-inflammatory drugs seemed to reduce Alzheimer’s disease. So, aiming to sidestep the dangers of NSAIDs, they decided to see if a natural anti-inflammatory could produce the same results.5
Re-enter curcumin.
Researchers tested both a low-dose and a high-dose of curcumin on mice with Alzheimer-like pathology to see if the spice would reduce inflammation, oxidative damage, and plaque pathology.
They determined that curcumin significantly lowered several inflammation markers, in addition to reducing plaque on the brain (a sign of Alzheimer’s) by 43 to 50 percent.
They concluded that curcumin “shows promise for the prevention of Alzheimer’s disease.”
We think it does too, and without the dangerous side effects of NSAIDs.
However, what we’d really like to see is a gold standard human study that tests the effects of curcumin on Alzheimer’s disease. But this is a good start."

Where to Find Your Indian Gold…
"One of the easiest ways to enjoy all of the therapeutic benefits of curcumin is to use turmeric in cooking.
However, don’t confuse turmeric with curry powder. While both are yellow spices often used in Indian cuisine, curry is actually a blend of spices, only one of which is turmeric. You want the straight stuff…just turmeric.
Then you can go to town. Use it on any protein dish: fish, meat, or chicken. It also tastes fantastic mixed with lentils and garbanzo beans.
But don’t stop there. You can add turmeric to vegetables, rice, potatoes, and soups. Experiment and enjoy. The result will be delicious AND healthy.
If you are looking for a more concentrated health hit, you can also opt for curcumin supplements. The recommended dose is 450–600 mg per day. Just be sure to take it with a healthy fat, such as coconut oil or olive oil, to increase absorption.
And, as with all supplements, look for a product that is free from preservatives, fillers, binders, excipients, flow agents, shellacs, coloring agents, gluten, yeast, lactose, and other allergens. Ideally, you’ll also be able to find independent analysis done by a third party to verify the active ingredients and identify any contaminants.
Whether you choose to get cooking or rely on supplementation, turmeric and its powerful ally, curcumin, truly is worth its weight in gold.
1Chainani-Wu, N. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J. Altern. Complement. Med. 2003 Feb; 9(1):161-8.
2Satoskar, RR, et al. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int. J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4.
3Deodhar, SD, et al. Preliminary study of antirheumatic activity of curcumin (diferuloyl methane). Indian Journal of Medical Research. 1980; 71:632-4.
4Martin, BK, et al. Cognitive function over time in the Alzheimer’s Disease Anti-inflammatory Prevention Trial (ADAPT); results of a randomized, controlled trial of naproxen and celecoxib. Arch. Neurol. 2008; 65(7):896-905.
5Lim, GP, et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 2001 Nov 1; 21(21):8370-7.
6Aggarwal, BB et al. Anticancer Potential of Curcumin: Preclinical and Clinical Studies. Anticancer Research. 2003; 23:363-98.
7Writing group for the Women’s Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA. 2002 July 17; 288(3):321-33.
8Carroll, CE, et al. Curcumin delays development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz[a]anthracene-induced mammary tumors. Menopause. 2010 Jan–Feb; 17(1):178-84.
9Li, M. et al. Curcumin, a dietary component, has anticancer, chemosensitization, and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res. 2007; 67(5):1988–96."

Curcumin: A Powdered Gold that Can Help Prevent Alzehiemer’s.  I buy my supplements from several vendors I know that do not have toxic chemical additives like magnesium stearate in them.  I usually buy products from this vendor online:  I prefer Pure Encapsulations because their products are free of additives and other noxious substances.

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